Publisher: Royal Society of Chemistry (RSC)

Issue:

License: [{"start"=>{"date-parts"=>[[2026, 12, 9]], "date-time"=>"2026-12-09T00:00:00Z", "timestamp"=>1796774400000}, "content-version"=>"am", "delay-in-days"=>342, "URL"=>"http://rsc.li/journals-terms-of-use"}]

Publication date(s): 2026 (online)

Pages:

Volume: Issue:

Journal: Physical Chemistry Chemical Physics

Link: [{"URL"=>"http://pubs.rsc.org/en/content/articlepdf/2026/CP/D5CP03860J", "content-type"=>"unspecified", "content-version"=>"vor", "intended-application"=>"similarity-checking"}]

Cofactor NAD +  regeneration is essential for enabling dehydrogenase-promoted biosynthesis. Supported heterogeneous catalysts, particularly Pt, represent an emerging approach, where Pt particle size is critical to catalytic performance.

Nicotinamide adenine dinucleotide (NAD+) cofactor regeneration is essential for enabling dehydrogenase-promoted biosynthesis for value-added chemicals. Heterogeneous catalytic cofactor regeneration, using supported metal catalysts, is an emerging approach and has shown great promise. However, mechanistic insight remains largely unexplored. In this work, a series of silica-supported platinum (Pt) catalysts have been prepared for NAD+ cofactor regeneration, to understand the roles of Pt particle size and structure. A turnover frequency (TOF) ‘volcano plot’ was obtained for Pt clusters in the range of 2.2–7.1 nm, with the maximum TOF (136 h−1) observed at 5.6 nm. Selective Pt site blockage with polyvinyl pyrrolidone (PVP) revealed that the significant structure sensitivity originated from the synergistic effect of under- and well-coordinated sites in size-varied Pt clusters. In addition, a facet preference was also identified, where the cofactor regeneration favoured the Pt(100) surface more than Pt(111). These findings provide the first insight into NAD+ regeneration using heterogeneous Pt catalysts, which will be particularly useful for the rational design of supported metal catalysts.

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