Concurrent Biocatalytic Oxidation and C–C Bond Formation via Gold Catalysis: One-Pot Alkynylation of N-Alkyl Tetrahydroisoquinolines
Concurrent Biocatalytic Oxidation and C–C Bond Formation via Gold Catalysis: One-Pot Alkynylation of N-Alkyl Tetrahydroisoquinolines
Authors (3): M. Odachowski, M. F. Greaney, N. J. Turner
Themes: Biocatalysis
DOI: 10.1021/acscatal.8b03169
Citations: 37
Pub type: article-journal
Pub year: 2018

Publisher: American Chemical Society (ACS)

Issue: 11

License:

Publication date(s): 2018/11/02 (print) 2018/09/21 (online)

Pages: 10032-10035

Volume: 8 Issue: 11

Journal: ACS Catalysis

Link: https://pubs.acs.org/doi/pdf/10.1021/acscatal.8b03169

URL: http://dx.doi.org/10.1021/acscatal.8b03169

A cross-dehydrogenative coupling process has been developed involving the enzymatic oxidation of tetrahydroisoquinolines (THIQ) together with gold-catalyzed C–C bond-formation. The transformation demonstrates the compatibility of gold-mediated chemocatalysis and monoamine oxidase biocatalysis which act co-operatively in one vessel. A range of N-alkyl THIQs were functionalized in this manner at C-(1) position in high yields.

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cs8b03169_si_001.pdf Supl. data for Concurrent Biocatalytic Oxidation and C–C Bond Formation ... 2018


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