Authors (4): X. Tang, M. Demiray, T. Wirth, R. K. Allemann
Themes: Biocatalysis DOI: 10.1016/j.bmc.2017.03.068
Citations: 28
Pub type: article-journal
Pub year: 2018
Publisher: Elsevier BV
Issue: 7
License: https://www.elsevier.com/tdm/userlicense/1.0/
Publication date(s): 2018/04 (print)
Pages: 1314-1319
Volume: 26 Issue: 7
Journal: Bioorganic & Medicinal Chemistry
Link: https://api.elsevier.com/content/article/PII:S0968089617301268?httpAccept=text/xml
URL: http://dx.doi.org/10.1016/j.bmc.2017.03.068
Artemisinin is one of the most potent anti-malaria drugs and many often-lengthy routes have been developed for its synthesis. Amorphadiene synthase, a key enzyme in the biosynthetic pathway of artemisinin, is able to convert an oxygenated farnesyl diphosphate analogue directly to dihydroartemisinic aldehyde, which can be converted to artemisinin in only four chemical steps, resulting in an efficient synthetic route to the anti-malaria drug.
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